Charles Floyd (1782 - August 20, 1804) was a United States explorer, a non-commissioned officer and quartermaster in the Lewis and Clark Expedition. A native of Kentucky, he was a relative of William Clark and cousin of the politician John Floyd.

While exploring the Louisiana Purchase with Lewis and Clark, he took ill at the end of July 1804. On July 31st, Floyd wrote in his diary, "I am verry sick and has been for Sometime but have Recovered my helth again." However, this apparent recovery was soon followed by a severe turn for the worse. William Clark described Floyd's death as one "with a great deal of composure" and that before Floyd died he said to Clark: "I am going away. I want you to write me a letter."

A funeral was held and Floyd was buried on a bluff overlooking the Missouri River, which the expedition named Floyd's Bluff in his honor.

Clark diagnosed the condition which led to Floyd's demise as bilious colic, though modern doctors and historians agree Floyd's death was more likely to have been caused by a ruptured appendix. The brief "recovery" Floyd described may have represented the temporary relief afforded by the bursting of the organ, which would have been followed by a fatal peritonitis. If that were the case, because there was no known cure for appendicitis at that time, he would have been no better off had he been with the best physicians of the day.