Regina ( ) is the capital of Saskatchewan, Canada, making it the seat of the provincial Crown. The city is the second largest in the province (after Saskatoon), and is a cultural and commercial metropole for both southern Saskatchewan and adjacent areas in the neighbouring American states of North Dakota and Montana. It attracts visitors for the vitality of its commerce, theatre, concerts and restaurants and to its summer agricultural exhibition (originally established in 1884 as the Assiniboia Agricultural Association and since the mid-1960s styled "Buffalo Days" ). It is governed by Regina City Council. Regina is the cathedral city of the Roman Catholic and Romanian Orthodox Dioceses of Regina and the Anglican Diocese of Qu'Appelle. Citizens of Regina are referred to as Reginans.

Regina was previously the headquarters of the North-West Territories, of which today's provinces of Saskatchewan and Alberta originally formed part. Regina was the headquarters of the District of Assiniboia. Regina was named in 1882 after Queen Victoria, i.e. Victoria Regina, by her daughter Princess Louise, wife of the then-Governor General the Marquess of Lorne.

Unlike other planned cities in the Canadian West, on its treeless flat plain Regina was a tabula rasa, without topographical features other than the small spring run-off Wascana Creek. Early planners took advantage of such opportunity by damming the creek and creating a decorative lake to the south of the central business district; Regina's importance was secured when the new province of Saskatchewan designated the city its capital in 1906. Wascana Centre, created around the artificial focal point of Wascana Lake, remains Regina's signal attraction and contains the Provincial Legislative Building, both campuses of the University of Regina, the provincial museum of natural history, the Regina Conservatory (in the original Regina College buildings), the Saskatchewan Science Centre, the Norman Mackenzie Art Gallery and the Saskatchewan Centre of the Arts.

Residential neighbourhoods in Regina are largely indistinguishable from those in other western Canadian cities but several precincts beyond the historic city centre are historically or socially noteworthy. Immediately to the north of the central business district is the old warehouse district, increasingly the focus of shopping and residential development; as in other western cities of North America, the periphery contains shopping malls and big box stores. Generally a prosperous and tranquil city, its long-problematic north-central sector and the difficult Scott Collegiate have in recent years become the focus of national attention for their poverty, drug abuse and prostitution. Regina is notable for its aboriginal and Métis population, the seventh largest in any Canadian urban centre (Regina is Canada's 18th-largest metropolitan area by population ), the original North-West Territories Government House and the original North-West Territorial government buildings. In 1912, Regina was a focus of international attention when the Regina Cyclone destroyed much of the town; in the 1930s, the Regina Riot brought further attention and, in the midst of the 1930s drought and Great Depression, which hit the Canadian Prairies particularly hard with their economic focus on dryland grain farming, the CCF (now the NDP, an important left-wing political party in all provinces west of Quebec), formulated its foundation Regina Manifesto in Regina. In recent years, Saskatchewan's resources have come into new demand, and it is anticipated that it will enter into new period of strong economic growth.