The Knicks-Nuggets Brawl was an on-court altercation at a National Basketball Association game between the New York Knicks and Denver Nuggets at Madison Square Garden, New York City, New York, on Saturday, December 16, 2006. This altercation was the most penalized on-court fight in the NBA since the infamous Pacers-Pistons brawl of November 19, 2004.

The altercation began with a flagrant foul by New York player Mardy Collins on Denver player J. R. Smith in the closing seconds of the game, when it appeared the Knicks, especially New York coach Isiah Thomas, became enraged by the perceived unsportsmanlike running up the score by the Denver Nuggets. Denver, despite having a comfortable lead, still had their starters on the floor. Thomas himself also had apparently verbally warned Nuggets star Carmelo Anthony to not go into the paint. The foul touched off a brawl that ultimately led to the ejection of all ten players on the court and suspensions to seven players. The longest of these suspensions was Denver's Carmelo Anthony lasting 15 games.