Garfield: A Tail of Two Kitties (also known as Garfield 2: A Tail of Two Kitties in the UK, Garfield: The Movie 2 or its working title Garfield 2) is a theatrical sequel to the 2004 live-action feature film Garfield: The Movie. This film was directed by Tim Hill, written by Joel Cohen & Alec Sokolow, produced by Davis Entertainment for 20th Century Fox, and was released in U.S. cinemas on June 16, 2006 (July 21, 2006 in UK). It borrows its storyline from Mark Twain's The Prince and the Pauper.

This film was rated PG by the MPAA for "some off-color elements."

Garfield is back and this time Garfield and his canine sidekick Odie follows their owner, Jon Arbuckle, to England, the U.K. may never recover, as Garfield is mistaken for a look-alike, regal cat who has inherited a castle. Garfield savors the royal treatment afforded by his loyal four-legged subjects, but his reign is in jeopardy! The evil nefarious stubborn Lord Dargis is determined to do away with Garfield, so he can turn the castle into a resort. Garfield's bigger, better, more perfect world is soon turned upside down in this tale of two kitties. Written by Anthony Pereyra

Jon goes to London to be with Liz and Garfield sneaks with him. Meanwhile a deceased Queen gives everything to her cat Prince XII. Her only heir Lord Dargis becomes jealous and tries to kill Prince. Garfield & Odie sneaks out to the streets of London. Lord Dargis throws Prince in the river and ends up in the sewer of London. Smithee the butler believes he found Prince but it was really Garfield and Jon find Odie with Prince and mistakes him for Garfield. Now the Castle animals must keep Garfield safe and keep him thinking he's royal to save their lives. Written by Anonymous