Frankford Creek is a minor tributary of the Delaware River in southeast Pennsylvania. The stream originates as Tookany Creek at Hill Crest in Cheltenham Township and meanders eastward, then southeastward, throughout Cheltenham Township, until a sharp bend near the Philadelphia border at Lawncrest, where the place names Toxony and Tookany were used in historic times; the stream is still known as Tookany Creek in this region, where it flows southwest. Turning south into Philadelphia at the crotch of Philadelphia's Y-shaped border, the creek is called Tacony Creek; from here southward, it is considered the informal boundary separating Northeast Philadelphia from the rest of the city. The Philadelphia neighborhoods of Olney and Feltonville are on the western side of the stream in this area while Northwood, Oxford Circle, and Frankford are on the eastern side. It continues to be called the Tacony at least until the smaller Wingohocking Creek merges with it in Juniata Park, within the city-owned golf course. Beyond Castor Avenue it is known as Frankford Creek until the stream's confluence with the Delaware River in the Bridesburg section of Philadelphia, Pennsylvania.

The Lenni Lenape Native Americans who lived within its watershed called the creek Quessionwonmink, which means “Eel Skin River.” Some believe the word Tacony to be derived from another Lenni Lenape word meaning "forest" or "wilderness".

Portions of its tributary Wingohocking Creek were converted to sewers between 1905 and 1915.

In 1934, the creek's path through Frankford was straightened as two horseshoe bends were removed in the vicinity of the intersection of Wyoming and Castor Avenues. An arch structure, presumably the remains of a bridge carrying Wyoming Avenue over one of the removed bends in the creek, is visible from park level (approximately 15 ft (5m) below Wyoming Ave.). A bridge railing along the sidewalk still exists in this location, across from what was Parkview Hospital. Downsteam from Castor Avenue, the creek now flows in a concrete culvert. In 1956 the creek was diverted to meet the Delaware River at a more southerly point, cutting off the loop in its natural bed through Bridesburg past the Frankford Arsenal.

Much of Frankford Creek's watershed has been converted to storm sewers, as this map discloses.