Ethicon Endo-Surgery, Inc., a subsidiary of Johnson & Johnson, is a company that designs and manufactures medical devices and surgical instruments with the intent of minimizing the invasiveness of surgery.

Ethicon Endo-Surgery was part of Ethicon, Inc. until 1992, when it became a separate corporate entity under the J&J umbrella.

The company's headquarters is in Blue Ash, a suburb of Cincinnati, Ohio. In addition to manufacturing surgical instruments, the company provides training for surgeons.